For example, long-lasting increased expression of CAV1 in such tissue caused by induction of its radioprotective effect without substantial endocytosis can lead to the development of RISIs such as chronic ulcers, whereas reduced content of CAV1 in this tissue caused by involvement of this protein in intensive endocytosis of EGFR will create conditions favoring the appearance of radiation dermatitis and radiation-induced fibrosis. This evidence concerns the gene CAV1 and radiodermatitis.