Another protective element is the reduction in the glutathione pool by drug metabolite—NAPQI, which may play a role in the sterilization of premalignant ovarian lesions; inhibition of tautomerization activity of macrophage migration inhibitory factor (MIF) released from ovarian cancer, which is necessary for normal ovulation; and blockade of cytokine-induced and endothelium-derived cyclooxygenase activity [102]. This evidence concerns the gene MIF and ovarian carcinoma.