The results are: (1) aggresomes (TRiC-PHD3) formation around the nuclear membrane, which trap vimentin protein; (2) compromised folding and stabilization of pVHL protein, leading to non-degradation of HIF and its translocation into the nucleus; (3) increased lipid biosynthesis; (4) high oxidative stress; (5) increased tumor aggressiveness. The gene discussed is VHL; the disease is neoplasm.