EGLN3 and glioblastoma: The CCT complex may indirectly influence the apoptosis process, modulating the folding/stability of the PHD3; since in GBM conditions, the hydroxylase activity of PHDs is reduced by the low oxygen concentration [82] and the decreased levels of α-KG, the CCT complex-dependent multiprotein complexes [83,84], including CCT-PHD3 [69], may not be formed, following inactivation of the hydroxylase function of PHD3 [70].