Under prolonged hypoxia typical of GBM, the accumulation of PDH3 together with the CCT chaperonins could lead to the formation of actual aggresomes capable of converging in the perinuclear region, thus contributing to the alteration of the organization of the cytoskeleton and leading to the formation of vimentin cages around them (Figure 2) [87]. This evidence concerns the gene FLVCR2 and glioblastoma.