CREB1 and Anxiety: Prolonged stress further impairs neuroplasticity-related pathways, including brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB)/cAMP response element-binding protein (CREB) and N-methyl-D-aspartate receptor (NMDAR)/Ca2+/calmodulin-dependent protein kinase II (CaMKII) signaling, leading to synaptic dysfunction and persistent anxiety [9].