Gut-derived pathogen-associated molecular patterns (PAMPs) and Staphylococcus aureus products have been reported to activate the NLR family pyrin domain containing 3 (NLRP3) inflammasome in experimental models, which can be accompanied by IL-1β and IL-18 release and enhanced Th17/IL-22 signaling; however, the extent to which this pathway drives clinical AD in humans remains to be fully established [9]. Here, NLRP3 is linked to Alzheimer disease.