In contrast, Wang KZ [11,31] reported that the deSUMOylation of TFEB enhanced the transcriptional activity of TFEB, increased lysosomal production and autophagy, and inhibited the formation of macrophage foam cells, resulting in subsequently decreased lipid deposition in bone marrow-derived macrophages and C57BL/6 mice, ultimately inhibiting the development of atherosclerosis. This evidence concerns the gene TFEB and atherosclerosis.