-metformin was an effective additive in advanced and chemotherapy-/cisplatin-/paclitaxel-resistant OC in preclinical studies [162,163,164,165,166,167,168,169,170]-metformin decreased carboplatin-induced ovarian damage in rats [171]--metformin enhances the antitumor effect of PD-L1 inhibitors in a mouse model of OC [172]-IACS-010759 delayed tumor progression and improved survival in an orthoptic patient-derived OC xenograft model [173]-ONC201 inhibits tumor growth and decreases VEGF expression in vivo [174]. This evidence concerns the gene CD274 and neoplasm.