Massani et al. [136] reported that long-term s-μg (RPM) altered pancreatic cancer cell morphology by activating Rho/Cdc42-mediated actin remodeling, promoted 3D spheroid formation and epithelial-to-mesenchymal transition, and activated the ERK5/NF-κB/IL-8 axis, expanding migratory cancer stem cells. Here, RHO is linked to familial pancreatic carcinoma.