Three cases (0.08%, n = 3/3960) expressing NTRK1 fusions (RRP15-NTRK1, NAV1-NTRK1, and one case with both PEAR1-NTRK1 and NTRK1-STK11 fusions) were detected in esophagogastric adenocarcinoma (esophageal, esophagogastric, or gastroesophageal junction). This evidence concerns the gene NAV1 and gastroesophageal junction adenocarcinoma.