JAK2 and lung carcinoma: Keeratichamroen et al. reported that three SLs isolated from Gymnanthemum extensum—vernodalin (VDa), vernolepin (VLe), and vernolide (VLi)—exerted dose-dependent cytostatic and cytotoxic effects against A549 lung cancer cells by modulating the JAK2/STAT3 pathway [49].