Furthermore, MR exploits specific genetic lesions; for instance, cancers harboring methylthioadenosine phosphorylase deletions accumulate methylthioadenosine, rendering them synthetically lethal to methionine adenosyltransferase 2A (MAT2A) inhibition and protein arginine methyltransferase 5 (PRMT5) suppression due to a complete collapse of the salvage pathway [118]. The gene discussed is MAT2A; the disease is cancer.