MCAT and Alzheimer disease: Oxidatively modified RNAs and elevated mitochondrial transcripts (for example NADH dehydrogenase subunits MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6 mRNA, ATP synthase subunits MT-ATP6, MT-ATP8 mRNA and cytochrome c oxidase subunits MT-CO1, MT-CO2, MT-CO3) in plasma EVs, and markers of RNA oxidation such as 8-hydroxyguanosine (8-OHG), have been reported in preclinical models and human samples [66,72], supporting the view that exRNA patterns capture early metabolic and transcriptional disturbance in AD.