A landmark study in rheumatoid arthritis models elegantly delineated the differential roles of these two receptors, demonstrating that CXCL10-induced migration of macrophages and T cells is exclusively CXCR3-dependent, whereas induction of pro-inflammatory and osteoclastogenic cytokines such as RANKL, TNF-α, and IL-6 requires cooperative engagement of both CXCR3 and TLR4 [75]. The gene discussed is CXCL10; the disease is rheumatoid arthritis.