NP can be employed for localized delivery of pathway inhibitors; for example, in a murine model of inflammatory bone loss relevant to OS, local injection of the CXCR3 antagonist AMG487 encapsulated in nanoparticles effectively reduced inflammation, decreased osteoclast numbers, and prevented bone resorption, demonstrating the potential to disrupt the pro-tumor vicious cycle without systemic toxicity [202]. This evidence concerns the gene CXCR3 and neoplasm.