Co-culture studies of OS cell lines with THP1-derived M0 or M2 macrophages revealed marked CXCL10 upregulation compared with monocultures, suggesting that CXCL10 contributes to macrophage polarization toward a tumor-promoting M2 phenotype and helps sustain their immunosuppressive activity [17]. The gene discussed is CXCL10; the disease is neoplasm.