This concept is supported by findings from Pein et al. [141], who showed in a breast cancer model that metastatic cells induce lung fibroblasts to upregulate CXCL9 and CXCL10 via JNK/IL-1/NF-κB signaling, fostering an inflammatory microenvironment conducive to tumor colonization. The gene discussed is CXCL9; the disease is neoplasm.