For example, in glioblastoma, a multifunctional NKCE that binds the activating receptor NKp46 on NK cells, a tumor-specific antigen on GBM cells, and incorporates a domain that locally releases CXCL10, significantly enhanced CXCR3+ NK cell recruitment and anti-tumor activity [192], illustrating its potential application in OS. The gene discussed is NCR1; the disease is glioblastoma.