CXCL10 and neoplasm: Accumulating evidence suggests that CXCL10 helps establish a highly structured immune architecture within the tumor; for instance, NK cells and T cells can occupy distinct spatial niches relative to the expression of major histocompatibility complex class I (MHC-I) on tumor cells, indicating that chemokine gradients, including CXCL10, help organize distinct immune compartments [161,162,163].