In several malignancies, such as summarized in Table 2 including OS, high intratumoral expression of CXCL10 and/or its receptor CXCR3 correlates with an increased abundance of CD8+ T cells, pro-inflammatory M1 macrophages, and activated NK cells, all indicative of a robust anti-tumor immune milieu and improved patient outcomes [25,28,51,126,159]. This evidence concerns the gene CD8A and neoplasm.