APOC1 and Alzheimer disease: Correlation analysis revealed distinct regulatory patterns: in Ctrl samples, CI strength and APOC1 expression were inversely correlated (r = −0.56, p = 0.09), whereas a positive, though nonsignificant, correlation was observed in AD samples (r = 0.39, p = 0.15), implying disease-associated alterations in the relationship between chromatin architecture and gene expression.