Compared with the PBS control group set as 1, the relative expression of p-Cofilin was significantly decreased to 0.77 ± 0.02 and 0.58 ± 0.06 (n = 3) in the M08 and M039 groups, respectively (Figure 5A,B), suggesting that administering M08 and M039 could cause a significant reduction in p-Cofilin levels in ALS-like cells compared with the control. The gene discussed is CFL1; the disease is amyotrophic lateral sclerosis.