Preclinical evidence demonstrates that Moringa oleifera modulates important signaling pathways, including YAP/TAZ, Wnt/β-catenin, Nrf2-Keap1 and TLR4/NF-κB, which play divergent roles depending on the tumor cellular context, microenvironment, and cancer-related immune-metabolic axis [152]. The gene discussed is TLR4; the disease is neoplasm.