In addition, in colorectal tumors, Bifidobacterium adolescentis activates the Wnt/β-catenin pathway and induce high expression of GAS1 in CD143+ CAFs; given the tumor-suppressive role of GAS1, this axis may provide novel therapeutic targets for probiotic-based modulation of the TME [91]. The gene discussed is GAS1; the disease is neoplasm.