Muller et al. [67] studied 553 serum samples from pregnant women for CMV IgG and IgM antibodies and IgG avidity and, in addition, also studied anti-CMV IgM antibodies against recombinant p52 (defines early phase of infection) and anti CMV IgG antibodies against glycoprotein B (that defines late phases of infection by ELISA. The gene discussed is CD40LG; the disease is infection.