To achieve a clearer picture of what interactions may occur in the absence of stabilizing mutations, the structures of p53 and the BCL-2 family proteins generated by AlphaFold or ESMFold were analyzed using the LZERD web server (West Lafayette, IN, USA) to predict interactions with WT p53, as well as p53 R273C and p53 R273H, which are common p53 variants in cancer patients [24]. This evidence concerns the gene BCL2 and cancer.