STUB1 and congenital secretory chloride diarrhea 1: Recent genomic analyses across 214,563 individuals from four large cohorts (Framingham Heart Study, Atherosclerosis Risk in Communities Study, UK Biobank, and Mass General Brigham Biobank), demonstrated that CHIP was associated with a twofold higher risk of both prevalent and incident CLD (p < 0.001), as well as imaging-detected hepatic inflammation and fibrosis.