Notably, the investigation highlighted CHIP as a risk factor for CVD, revealing associations with composite cardiovascular events (HR 1.40; 95% CI, 1.19–1.65), CAD (HR 1.76; 95% CI, 1.27–2.44), stroke (HR 1.16; 95% CI, 1.05–1.28), and HF (HR 1.27; 95% CI, 1.15–1.41). Here, STUB1 is linked to stroke disorder.