This concept is illustrated in Figure 4, which depicts the bidirectional interplay between obesity and CHIP, where systemic inflammation and metabolic stress foster the expansion of mutant hematopoietic clones, while CHIP-associated inflammatory activity further exacerbates obesity-related metabolic dysfunction, establishing a self-reinforcing vicious cycle. The gene discussed is STUB1; the disease is obesity due to melanocortin 4 receptor deficiency.