YAP1 and malignant colon neoplasm: Interestingly, ω-3 PUFAs, such as DHA and EPA, were found to induce the phosphorylation of YAP and its retention in the cytoplasm through the activation of MST1/2–LATS1 via GPR40/120 and PKA, resulting in the activation of the Hippo pathway, which reduced growth and induced apoptosis in colon cancer cells [61].