Additionally, the extract had direct inhibitory effects on enzymes involved in the degradation of the ECM, especially the downregulation of MMP9 and MMP2 and the increase in TIMP-1 and TIMP-2 in cancer cells, which promotes a negative balance of ECM destruction [65,66], reflecting a dual regulation mechanism between MMPs and TIMPs [66,67]. The gene discussed is MMP2; the disease is cancer.