Also, KLK7 is expressed in neurons and glia, participates in ECM turnover, and can directly cleave the plaque-forming amyloid-β (Aβ) peptides of 36 to 43 residues length, which potentially supports neuroprotection and prevents Alzheimer’s disease (AD) [229]. Here, KLK7 is linked to early-onset autosomal dominant Alzheimer disease.