In fact, numerous investigations have studied the function of ILK in physiological contexts, such as vascular development [13,14,15], as well as in pathophysiological contexts, such as the maintenance of vascular and endothelial integrity [18,19], vascular tone [31,32,33] and the regulation of ECM proliferation, migration, and synthesis in smooth muscle cells [34], processes essential for the repair of lesions in vascular pathologies, such as atherosclerosis and restenosis. The gene discussed is ILK; the disease is atherosclerosis.