TP53 and non-small cell lung carcinoma: For instance, DHRS4-AS1 inhibits proliferation and stemness in non-small-cell lung cancer by sequestering miR-224-3p and upregulating TP53 and TET1 and induces apoptosis in hepatocellular carcinoma by the miR-522-3p/SOCS5 pathway [26,27].