IL10 and myocardial infarction: Several research studies demonstrated that priming MSCs with pro-inflammatory cytokines shifts their secretome toward an immunomodulatory and anti-fibrotic profile, including the increased production of indoleamine 2,3-dioxygenase (IDO), PGE2, and interleukin-10 (IL-10) [50,51], all of which are important for cardiac remodelling after myocardial infarction [52].