Interestingly, a positive feedback loop of regulation was seen in the case of β-catenin and c-MYC, where in lung adenocarcinoma, the circular RNA circXPO1 binds IGF2BP1 and enhances the stability of β-catenin mRNA, driving Wnt/β-catenin activation, tumor growth, and poor clinical outcomes [49]. Here, IGF2BP1 is linked to neoplasm.