Mice heterozygous for Pgc-1α and fed a high-fat diet develop hallmark AMD-like features, including BrM thickening, APOE/APOJ-positive drusen-like deposits, increased ROS levels, mitochondrial impairment, bisretinoid accumulation, and defective autophagy [90]. The gene discussed is PPARGC1A; the disease is age-related macular degeneration.