TNF and synovial sarcoma: Indeed, in HT and SS, the damage to the thyroid and salivary glands is caused by the activation of an immunological cascade triggered by cytotoxic CD8+ T lymphocytes through the release of interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) and the activation of the FAS/FAS ligand pathway [7].