GRN and frontotemporal dementia: In case of FTD, mutations in the genes MAPT, GRN, C9orf72, and transmembrane protein 106B (TMEM106B) produce mutated proteins that localize in the lysosome and cause lysosomal dysfunction by altering lysosomal fusion, cargo trafficking, and lysosomal acidification, thereby modulating autophagy [211].