SORBS1 and cancer: For instance, in cancer models, miRNA-223-3p has been shown to promote cell proliferation and invasion by targeting FBXW7 (F-box and WD repeat domain-containing 7), while also influencing intercellular communication and tissue responses by suppressing SORBS1 (Sorbin and SH3 domain-containing protein 1) through microvesicles released from cancer-associated fibroblasts [33,34].