Tan IIA reduced NFT and the inflammatory response and oxidative stress reaction in the hippocampus of AD rats, by upregulating the expression of CREB, BDNF, and tropomyosin receptor kinase B (TrkB) in the hippocampal tissue of streptozotocin-injured rats (Table 2) [100]. The gene discussed is CREB1; the disease is Alzheimer disease.