This suggests that nutritional medicine targeting PI3K/AKT and GSK3β signaling could represent a potential preventive and regenerative therapy to minimize the impact of extrinsic mediators on aging transitions (e.g., inflammatory states, oxidative stress, obesity, systemic insulin resistance) while also implementing neuroprotective measures in both T2DM and AD. This evidence concerns the gene GSK3B and type 2 diabetes mellitus.