Lastly, oral administration of 300 and 400 mg/kg of polyphenol-rich Boswellia serrata gum extract remarkably suppresses brain insulin resistance and pro-inflammatory cytokines to reverse cognitive decline by enhancing GSH, SOD, and glutamate receptors and inhibiting GSK3β activity in the hippocampus of T2DM rats [67]. The gene discussed is SOD1; the disease is type 2 diabetes mellitus.