In 2021, analysis of genotype distributions for the three SNPs (LEP rs7799039, LEPR rs1137101, and PGC1A rs8192678) in patients with RRMS or SPMS and controls revealed that only the PGC1A rs8192678 minor allele was linked to a higher MS risk [230]. The gene discussed is PPARGC1A; the disease is myeloid sarcoma.