These signaling pathways intersect with the molecular processes driving AD pathology: JAK2/STAT3 and PI3K/Akt activation promote anti-apoptotic and pro-survival gene transcription, while AMPK activation and GSK-3β inhibition reduce tau hyperphosphorylation, stabilize microtubules, prevent NFT formation, and decreased soluble Aβ [255,256]. Here, MAPT is linked to Alzheimer disease.