An integration of scRNA-seq data from 44,120 immune cells in 17 human atherosclerosis samples identified key immune cell types, such as pro-inflammatory CD4+ CD28null T cells and dysfunctional TREM2-SPP1+ foamy macrophages, linked to atherosclerosis progression and poor outcomes, suggesting these as potential therapeutic targets for precision medicine [37]. This evidence concerns the gene SPP1 and atherosclerosis.