Furthermore, the identification of upregulated genes, such as SIRT1, SBDS, SRF, SPN, P2RX1, TEAD3, and SLITRK3, alongside downregulated genes, including KIF22, KIF25, GAS2L2, and HINT3, highlights a broad transcriptional reprogramming within endometriosis-affected tissues. This evidence concerns the gene SPN and endometriosis.