RAF1 and Zika virus infectious disease: The strategy employed by ZIKV (Zika Virus) is more complex: while studies show that its non-structural protein NS5 promotes microtubule (MT) acetylation, thus altering the cytoskeleton, HDAC6 acts as an anti-ZIKV factor by promoting the autophagic degradation of NS5; yet, similar to IAV, other research indicates that ZIKV infection is also influenced by the HDAC6 ubiquitin-binding zinc finger (ZnF) domain, potentially involving uncoating, suggesting its strategy encompasses cytoskeletal alteration and evasion of HDAC6-mediated autophagic degradation [61].