P2RY13 and type 2 diabetes mellitus: In line with this macrophage-centered pattern, the scRNA-seq localization indicates that IL1B and MMP9 function as broadly distributed inflammatory and matrix-remodeling mediators, whereas macrophage/monocyte-enriched P2RY13 links purinergic signaling to lipid handling within the atherosclerotic plaque in T2DM–AS.