In T2DM, IL1B correlated positively with activated mast cells and neutrophils but negatively with activated NK cells; MMP9 correlated positively with neutrophils and M0 macrophages but negatively with activated NK cells; P2RY13 correlated positively with neutrophils and M0 macrophages but negatively with CD8 T cells (Figure 7C). The gene discussed is MMP9; the disease is type 2 diabetes mellitus.