PPARGC1A and major depressive disorder: A preclinical study in transgenic mck-PGC-1α1 mice (muscle creatine kinase–PGC-1α1) demonstrated that overexpression of the PGC-1α–PPAR–KAT axis in skeletal muscle modulated the KP and protected against depression-like behaviors induced by chronic mild stress induced by the forced swim test [58].