Of the seven known WS genes (PAX3, MITF, SNAI2, SOX10, EDNRB, EDN3, and KITLG candidate genes), pathogenic variants in four WS genes (PAX3, SOX10, EDNRB, and EDN3) and one candidate WS gene (PAX8) were implicated in cases reviewed across 10 African countries. This evidence concerns the gene EDN3 and Werner syndrome.