Mechanistically, this effect in spheroids derived from MS-186 cells was accompanied by a significant reduction in the expression of EZH2, a histone methyltransferase of the polycomb repressive complex 2 (PRC2) that has been implicated in breast cancer aggressiveness and poor prognosis in TNBC [25,26]. The gene discussed is PRDM9; the disease is breast carcinoma.