KCNJ10 and epilepsy: Levers for modifying the slow variables include CRISPR based modifications of the programs of ion channels associated with the pathophysiology of epilepsy (e.g., SCN1A or KCNQ2 in specific subtypes), the restoration of Kir4.1 mediated K+ clearance by astrocytes, and the targeted attenuation of pro-convulsive inflammatory cascades (e.g., NF-kB/NLRP3 axis) [253].