Within the apoptosis-associated gene module [51,52], several pro-apoptotic genes—including BID (BH3-interacting domain death agonist), BAD (BH3-only death agonist), NOXA1 (NADPH oxidase activator 1), BNIP3 (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3), BIK (BCL2-interacting killer), and caspases (CASP2, CASP6, and CASP14) were significantly downregulated in NSCLC patients. The gene discussed is CASP6; the disease is non-small cell lung carcinoma.