In this study, we investigated the effects of GH and pegvisomant, alone or in combination with cisplatin or doxorubicin, on the protein expression of ABCB1, ABCG2, ABCA6, and ABCA8 in NSCLC cells (H1299, H1703, H1734, and LLC1), as these transporters are known mediators of GH-induced therapy resistance in multiple cancer types [10,11,14,21,37,55,56]. This evidence concerns the gene ABCB1 and cancer.