Is important to highlight that in a double-blind and placebo-controlled study of 12 patients with CKD (5 with IgA nephropathy, 2 with ANCA-associated vasculitis, 2 with hypertensive nephropathy, 1 with anti-glomerular basement membrane disease, 1 with reflux nephropathy, and 1 with chronic interstitial nephritis), as well as a control group of healthy patients, found that apelin reduced blood pressure and caused peripheral vasodilation in the CKD group. This evidence concerns the gene APLN and chronic kidney disease.