OPA1 and Alzheimer disease: In layer 2 of the inferior parietal lobule, aging is associated with increased Drp-1 levels (p ≤ 0.0001), decreased Opa-1 levels (p ≤ 0.0001), and unchanged Mfn-2 levels compared to controls, whereas AD demonstrates increased Drp-1 (p ≤ 0.0001) and Mfn-2 (p ≤ 0.0001) levels alongside decreased Opa-1 levels (p = 0.0115) (Figure 3A–C).