MFN2 and Alzheimer disease: In aging cases, layer 5 of the frontal cortex revealed decreased Mfn-2 (p = 0.0010) and Opa-1 levels (p = 0.0002) with stable Drp-1 levels compared to young controls, whereas AD cases showed increased Drp-1 (p = 0.0001) and Mfn-2 levels (p = 0.0001) accompanied by reduced Opa-1 levels (p = 0.0013) relative to aging cases (Figure 2D–F).