In AD cases, layer 3 of the cingulate gyrus demonstrated increased Drp-1 (p = 0.0350) and Mfn-2 (p ≤ 0.0001) levels along with decreased Opa-1 levels (p ≤ 0.0001) compared to aging cases (Figure 4A–C). The gene discussed is MFN2; the disease is Alzheimer disease.