In AD, Opa-1 levels demonstrate a decreasing trend (p = 0.0730) while Drp-1 shows an increasing tendency (p = 0.3236), though without statistical significance, associated with markedly elevated Mfn-2 levels (p ≤ 0.0001) compared to aging cases (Figure 5D–F). Here, MFN2 is linked to Alzheimer disease.