Thus, the characteristic pattern of mitochondrial dynamics alteration in AD is marked by a shift in mitochondrial dynamics towards fission and enhanced mitochondrial fragmentation, leading to destabilization of organelle membranes and compensation of increased Mfn-2 protein, which appears to enhance endoplasmic reticulum contact with moderately damaged mitochondria while directing irreversibly damaged mitochondria towards selective mitophagy. Here, MFN2 is linked to Alzheimer disease.