Given that a number of conserved molecular pathways play a role in both β-cell GSIS and skeletal muscle insulin-stimulated glucose uptake [35,36,37,38,39,40], it still remains to be determined if skeletal muscle TAS1R3 expression is altered during T2D pathogenesis and whether this is attributed to a potential novel role of TAS1R3 in insulin-stimulated glucose uptake. The gene discussed is TAS1R3; the disease is type 2 diabetes mellitus.