CYCS and colorectal cancer: In recent years, gliotoxin has garnered attention for its anticancer potential in breast cancer, with striking cytotoxic potency in tumoral cell lines such as MDA-MB-231, MDA-MB-468, and MCF-7 [134], in colorectal cancer, inducing apoptosis in several colorectal cancer lines [135], and in other cancer-derived cell types, including lung epithelial cells and chronic lymphocytic leukemia lines, via mitochondrial disruption, activation of Bax, caspases, and cytochrome c release [136].