MDM2 gene amplification or protein overexpression has been reported in a range of human malignancies, including dedifferentiated liposarcoma (DDLPS), breast cancer, glioblastoma, colorectal cancer, non-small-cell lung cancer (NSCLC), and urothelial carcinoma among others [14]. The gene discussed is MDM2; the disease is dedifferentiated liposarcoma.