SNCA and freckles: α-Synuclein-associated spots might therefore appear lighter in color (primarily due to altered melanosome distribution and epidermal thinning, while, under UVB exposure, α-synuclein may also attenuate melanin synthesis [27]) and less uniform (due to altered melanosome distribution) compared to common age spots; moreover, α-synuclein-associated spots may be less prone to regression than melasma [31,32].