A recent multicenter study demonstrated that phosphorylated α-synuclein can be detected in skin punch biopsies from normal-appearing sites, including the posterior cervical (neck) site, of patients with synucleinopathies, with high positivity rates (93–100% across PD, Dementia with Lewy Bodies (DLB), Multiple System Atrophy (MSA), and Pure Autonomic Failure (PAF)) and rare positives in healthy controls (~3%) [8]. Here, SNCA is linked to multiple system atrophy.