AGT and cardiac hypertrophy: Linmao Lyu et al. treated CFs with Ang II and found an increased release of exosomes from CFs, which in turn upregulated the expression of renin, angiotensinogen, AT1R and AT2R and enhance Ang II expression in cultured cardiomyocytes and exacerbated Ang II-induced pathological cardiac hypertrophy [122].