PRSS23 and congestive heart failure: Recently, Zicheng et al. demonstrated that during CHF, exosomal miR-1246 released from human umbilical cord mesenchymal stem cells (hucMSCs) specifically targets serine protease 23 (PRSS23), blocking the activation of Snail signaling/α-smooth muscle actin signaling, which in turn inhibits the expression of endothelial cell marker CD31 and promotes angiogenesis and attenuate hypoxia-induced myocardial tissue injury.