Under fibrotic conditions affecting the lung, liver, kidney, and skin, PAI-1 expression is markedly upregulated, leading to inhibited ECM degradation, as observed in models of bleomycin-induced pulmonary fibrosis and bile duct ligation-induced hepatic fibrosis [103,104,105,106,107,108]. This evidence concerns the gene SERPINE1 and Hepatic fibrosis.