In cortical homogenates from young patients, expression levels of Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), AKT serine/threonine kinase 2 (AKT2), Mammalian Target of Rapamycin (MTOR), and Forkhead box O3a (FOXO3A) genes were found to increase almost equally during the first 24 h after stroke, followed by a trend toward normalization at later stages. The gene discussed is NEK4; the disease is Stroke.